Name: John Wayne Casserole Recipe
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Cuisine: American
Ingredients: 1 lb ground beef; 1 can refrigerated biscuits; 1 onion, diced; 1 bell pepper, diced; 1 cup diced tomatoes; 1 packet taco seasoning; 1 cup sour cream; ½ cup mayonnaise; 1 cup shredded cheddar cheese

Jump to Recipe· 4.2 from 47 reviews

If you are craving a dish that brings together comfort and bold Southwestern flavors in one irresistible, cheesy package, then you must try the John Wayne Casserole Recipe. This hearty layered casserole features savory ground beef spiced just right, fluffy biscuit dough creating the perfect base, and a creamy, tangy topping that ties everything together beautifully. It’s the kind of meal that feels like a warm hug after a long day, perfect for family dinners or when you want to impress guests with minimal fuss. Let me take you through this beloved recipe that’s as satisfying as it is straightforward.

Ingredients You’ll Need

The image shows multiple clear glass and white bowls arranged neatly on a white marbled surface. In the front, there is a large clear glass bowl filled with raw ground meat that has a pinkish-red color and a coarse texture. Surrounding it are smaller bowls: one with bright red chopped bell peppers, one with thin, light orange shredded cheese, one with sliced red tomatoes, one with finely chopped white onions, and one with small white cubes of what looks like cheese or butter. Two small round white bowls hold dark green stuffed olives and a creamy white sauce. Additionally, there are two small shakers filled with black pepper and salt, and a blue package of round crackers placed neatly in the center. The overall layout is clean and organized, emphasizing the fresh ingredients. photo taken with an iphone --ar 4:5 --v 7

This recipe is a wonderful example of combining simple ingredients that you likely already have on hand, turning them into something spectacular. Each one is essential, from the rich ground beef that forms the heart of the casserole to the fluffy biscuits that add a comforting layer of texture and fluff.

1 lb ground beef: Choose lean or regular based on your preference; it’s the protein-packed base that gives this dish its savory punch.
1 can refrigerated biscuits: These create a soft, buttery crust that crisps just enough during baking.
1 onion, diced: Adds sweetness and depth of flavor to the beef mixture.
1 bell pepper, diced: Gives a fresh crunch and vibrant color to brighten the dish.
1 cup sour cream: Brings creaminess and a slight tang that balances the savory elements.
1 cup shredded cheddar: A sharp cheese melt topping that finishes the casserole with irresistible gooeyness.
½ cup mayonnaise: Enriches the creamy tomato-pepper mixture and keeps it luscious.
1 packet taco seasoning: Infuses the beef with that signature Southwestern spice mix that makes this recipe memorable.
1 cup diced tomatoes: Adds juicy bursts and color, making every bite vibrant and fresh.

How to Make John Wayne Casserole Recipe

Step 1: Prepare the Biscuit Base

Start by pressing the refrigerated biscuit dough evenly into the bottom of a 9×13-inch baking pan. This base will bake into a soft, slightly golden crust that perfectly supports all the layers to come. Make sure the dough is spread to the edges, creating a nice foundation for the hearty filling.

Step 2: Cook the Beef Mixture

In a skillet over medium heat, sauté the diced onion until translucent, then add the ground beef. Break it up with your spoon as it cooks. When the beef is browned and cooked through, stir in the taco seasoning packet to infuse it with that unmistakable southwestern flavor. This beef layer is the star of the John Wayne Casserole Recipe, so make sure to cook it well and drain any excess fat for the best texture.

Step 3: Layer the Beef Over the Biscuit Crust

Spread this seasoned beef mixture evenly over the biscuit crust in your pan. The contrast between the soft biscuit bottom and the spiced beef on top starts creating the magic in this dish.

Step 4: Prepare the Creamy Tomato-Pepper Topping

In a mixing bowl, combine the sour cream, mayonnaise, diced tomatoes, and diced bell pepper. This creamy layer adds moisture, freshness, and a slight tang that perfectly complements the savory beef. Spread it gently over the beef layer, covering all the edges so each portion will be rich and flavorful.

Step 5: Add the Cheesy Finishing Touch and Bake

Finally, sprinkle the shredded cheddar cheese generously on top of everything. Bake your John Wayne Casserole Recipe in a preheated 350°F oven for about 25 to 30 minutes, or until the cheese is melted, bubbly, and slightly golden. The result is a multi-textured casserole with layers of fluffy biscuit, meaty goodness, creamy tang, and gooey melted cheese that’ll have everyone coming back for seconds.

How to Serve John Wayne Casserole Recipe

A square slice of layered casserole sits on a white plate with a gold rim, placed on top of two similar plates. The casserole has three visible layers: the bottom layer is pale and soft, the middle layer is a thick mix of brown cooked ground meat, and the top layer is melted bright orange and yellow cheese that looks smooth and slightly shiny. In the background, more casserole slices are slightly blurred. The whole scene is set on a white marbled surface. Photo taken with an iphone --ar 4:5 --v 7

Garnishes

To elevate this casserole, consider topping it with fresh chopped cilantro or thinly sliced green onions. A sprinkle of crushed tortilla chips or a dollop of guacamole can add extra texture and flavor contrast that make each bite shine.

Side Dishes

This dish pairs perfectly with light sides, such as a crisp green salad with lime vinaigrette or a simple bowl of Mexican-style corn salad. Avoid heavy sides because the casserole itself is rich and filling; fresh and bright sides provide a refreshing balance.

Creative Ways to Present

For a fun twist on the John Wayne Casserole Recipe, try layering it in individual ramekins for personal portions or serving it alongside warmed flour tortillas for a build-your-own taco night vibe. You can also serve it with a side of pickled jalapeños or a splash of hot sauce for those who love extra heat.

Make Ahead and Storage

Storing Leftovers

Leftover John Wayne Casserole Recipe keeps well in an airtight container in the refrigerator for up to 3 days. The flavors actually meld together beautifully overnight, making the next-day meal even more delicious.

Freezing

This casserole freezes wonderfully. After baking, allow it to cool completely, then portion it into freezer-safe containers or wrap the whole pan tightly with foil and plastic wrap. It can be frozen for up to 3 months. Thaw overnight in the fridge before reheating.

Reheating

To reheat, warm individual portions in the microwave until heated through, or place the entire casserole in a preheated 350°F oven until bubbly and warmed. You might want to cover the dish with foil to prevent the top from over-browning during reheating.

FAQs

Can I substitute ground turkey for ground beef in the John Wayne Casserole Recipe?

Absolutely! Ground turkey is a leaner alternative and works well with the taco seasoning to maintain that Southwestern flavor. Just be mindful not to overcook it, as turkey cooks faster than beef.

Is there a way to make this casserole vegetarian?

Yes, you can substitute the ground beef with seasoned cooked lentils, black beans, or a plant-based meat alternative. Simply season it with the taco seasoning and cook until the flavors meld, then proceed as usual.

Can I add spice to make the casserole hotter?

Definitely. Adding diced jalapeños or a pinch of cayenne pepper to the beef mixture or creamy topping will bring some heat. You can also serve it with spicy salsa or hot sauce on the side.

What kind of biscuits work best for this recipe?

Refrigerated biscuit dough from the grocery store is perfect for ease and consistent results. But if you prefer making your own from scratch or using pre-made biscuit dough without preservatives, that will work beautifully too.

Can I prepare this recipe ahead of time and bake later?

Yes, you can assemble all the layers in your baking dish, cover it tightly, and refrigerate it for up to 24 hours before baking. Just add a few extra minutes to the baking time if baking it straight from the fridge.

Final Thoughts

The John Wayne Casserole Recipe is one of those meals that feels like a celebration of down-home comfort food infused with lively Southwestern flair. It’s easy to prepare but delivers layers of flavor and texture that keep everyone at the table smiling. Whether you’re feeding a family or looking for a crowd-pleaser, this casserole is a terrific choice. Give it a try soon and make it your own—it just might become a beloved staple in your kitchen!